The DgHBPs identified have been sequenced and have been found to exhibit a two-domain organisation. 11 (7), 488-95) followed by interchain covalent cross-linking during maturation, with the very high cross-link density imparting the beak with its impressive mechanical properties (Miserez et al. DgHBP coacervates have been hypothesized to infiltrate the chitin-DgCBPs scaffold (Tan et al. DgCBPs likely bind to chitin to form a chitin-DgCBPs scaffold, while DgHBPs exhibit self-coacervation ability, a liquid-liquid phase separation (LLPS) process resulting in the formation of highly concentrated protein microdroplets. The squid beak proteins were recently isolated and sequenced and two families of proteins, chitin binding beak proteins (DgCBPs) and histidine-rich beak proteins (DgHBPs) were discovered within the beak. The Humboldt squid beak includes a hard biomolecular composite made of chitin and proteins. The present invention lies in the field of targeted delivery of active agents using peptide coacervates and methods of coacervate formation and active agent encapsulation.
19, 2019, and is being submitted electronically via EFS-Web. The text file is 28 KB, was created on Jun. The name of the text file containing the Sequence Listing is 690148_558_SEQUENCE_LISTING.txt.
The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification.
20, 2018, the disclosures of which is incorporated herein by reference in its entirety. 10201805304Y entitled “Peptide Coacervates For Encapsulation of Insulin With High Efficiency And Glucose-Responsive Release”, filed on Jun. This application claims priority to Singapore Application No.
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